1. What is Phellinus linteus?
Phellinus linteus is included in Phellinus genus of Hymenochaetaceae family of Aphylloporales order in mushroom class (Basidiomycetes) that mostly consists of fungi of medical use and edible fungi among molds. It grows naturally on the trunks of the mulberry tree and its nomenclature is Phellinus linteus (Berk. Et Curt) Aoshima. In Korea, it is called academically as Phellinus linteus and called as Sang-Hwang in galenical name. There are a lot of disputes related to Phellinus linteus and various names such as P. igniarius (L. ex Fr.) Quel, P. yucatensis (Murr.) Imazek., Fomes yucatensis Murrill., Pyropolyporus yucatensis Murr., etc. are used for Phellinus linteus.
Phellinus linteus is written as Sang-I in "Shin-Nong-Bon-Cho-Kyung" of China, Sang-hwang and Sang-shin in Yak-Sung-Ron of Gyeon Ip-an in Tang era of China, Ho-son-an in Yu-Yang-Jap-Jo of Dan Seong-sik, Sang-Hwang-Go in Chan-Yo-Gi-Bang, Sang-I and Sang-Hwang in Bon-Cho-Gang-Mok of Lee Si-Jin in Ming Dynasty of China and Sang-I and Sang-Hwang in Dong-I-Bo-Gam of Her Jun. In addition, Big Dictionary of Chinese Medicine (Joong-Yak-Dae-Sajeon)(Sanghai Science Publishing Company) has the terms such as Sang-shin, Sang-I, Sang-Hwang-Go and Ho-Son-An because Phellinus linteus is the mushroom that grows naturally on the trunks of willow, paper mulberry and elm tree and generally defines all terms as Phellinus linteus. However, the special book, "Chinese Fungi for Medical Use" that is written by Ryu Pa (Sanseo People's Publishing Company, published in 1978), defines only the mushroom that grows naturally in the trunks of the mulberry as the real Phellinus linteus, and its nomenclature is Pyropolyporus yucatensis Murr. in this book. Meanwhile, in accordance with the first volume (1975) of Japanese Fungi Color Illustration Book that is written by ô¹õ½ôèìé (San-Chon-Cheong-Il) and the second volume (1987) of Japanese Fungi Color Illustration Book by Rokuya Imazeki, Pyropolyporus yucatensis Murrill, Fomes yucatensis Murrill is other name of Mesimakof Phellinus linteus (Berk. et Curt) Aoshima in Japanese and Mesimakof is defined as Sang-Hwang in Chinese character because it naturally grows on the mulberry and all parts except the surface of mushroom is yellow. Therefore, Phellinus igniarius is not the real nomenclature for Phellinus Linteus but the general nomenclature, and Phellinus linteus (Berk. et Curt) Aoshima is the true nomenclature for Sang-Hwang, Phellinus linteus.
Picture. Fruit Body of Phellinus linteus (Sang-Hwang)
2.Cultivation Technology of Phellinus linteus Mycelia
Han Kook Shin Yak aims to search and optimize the condition to effectively produce Phellinus linteus mycelium and to develop the mass production technology through scale-up and tries to do its best to develop the technology that can produce better products.
Phellinus linteus ( Sang-Hwang) that is included in Phellinaceae is very rare in the nature so that it is very difficult to find it as well as to separate and artificially cultivate mycelium. Recently, it is reported that the artificial cultivation of a fruit body is successfully completed, but it is not certain whether it is ture or not. The effect as anti-cancer immuno-stimulating substance was found in the earlier stage but the mass production technology is not fully developed. Therefore, it is required to develop the new technology for mass production. Then, Han Kook Shin Yak developed Mesima that provides the constant anti-cancer effect through the solid cultivation and fluid cultivation of good strain that the activation is strong among Phellinus linteus in 1991 and registered the patent and acquired the approval to produce the medical supplied using Mesima. On the basis of those activities, Han Kook Shin Yak is significantly contributing to the anti-cancer treatment.
Picture. Mesima Cultivation using Fermentation Facility of 12 ton
3. New Phellinus linteus Strain Development
The marvelous effect of Phellinus linteus was reported in Japan National Cancer Center in 1968, but the research in Japan was stopped because of rare fruit body of Phellinus linteus and difficulty of mass cultivation of strain. However, in Korea, the continuous efforts of Han Kook Shin Yak and joint research with the team of Dr. Yoo Ick-Dong of Korea Research Institute of Bioscience and Biotechnology on G7 project that the Ministry of Science and Technology supervises for 10 years enabled the mass cultivation of strains that produce anti-cancer immuno-stimulating substances and the mass production of substances for medical use for the first time in the world. Han Kook Shin Yak secured the superior strains during G7 project period and developed Phellinus linteus Yoo (HKSY-PL2) that has the highest anti-cancer immuno-stimulating substance.
Picture. Mycelium of Phellinus linteus Yoo (HKSY-PL2)
The authenticity of HKSY-PL2 strain to produce the strong anti-cancer immuno-stimulating substance could be examined through gene interpretation and HKSY-PL2 strain that was approved as a result of the examination was named exactly as Phellinus linteus Yoo and obtained the patent.
Han Kook Shin Yak tries to develop new strain for Mesiam production to provide best Mesima product in quality and to increase the medical effect of Mesima. One of the development efforts, Han Kook Shin Yak collects Phellinus linteus strains and judges the authenticity through DNA analysis by PCR. Phellinus linteus strains that are selected through authenticity examination are selected as candidates for new Mesima production strains by the consideration on the stability of strains and the productivity of anti-cancer immuno-stimulating substances through already acquired and stabilized mass production technology of the high level. The selected strains will be secured as new strains as considering HKSY-PL2 that is current Mesima production strains, medical effects and productivity.
Han Kook Shin Yak will continuously put every efforts on the process mentioned above in order to develop better Mesima products and continue to invest for the research and development in order to make Mesima the best anti-cancer immuno-stimulating substance without keeping the current capability
Picture. Gene Interpretation Chart of Mesima
(Presented by the Japanese Society of Pharmacognosy, 2001)